Hypoxic-ischemic encephalopathy affects around 3 newborns every 1000 term births per year. The only available treatment for hypoxic-ischemic encephalopathy is therapeutic hypothermia, which is performed on patients presenting with a moderate or severe encephalopathy. In this thesis study, the aim is to investigate the presence and the prognostic value of early perinatal markers able to predict the severity of the neuropsychiatric sequelae at 18-24 months in patients previously treated with therapeutic hypothermia. The correlation of perinatal markers, routinely used in clinical practice, and neuropsychiatric outcomes is investigated and a control group is established in order to distinguish the markers which are truly predictive from those that are increased for other reasons but unspecific for hypoxic-ischemic damage.
Hypoxic-ischemic encephalopathy affects around 3 newborns every 1000 term births per year. The only available treatment for hypoxic-ischemic encephalopathy is therapeutic hypothermia, which is performed on patients presenting with a moderate or severe encephalopathy. In this thesis study, the aim is to investigate the presence and the prognostic value of early perinatal markers able to predict the severity of the neuropsychiatric sequelae at 18-24 months in patients previously treated with therapeutic hypothermia. The correlation of perinatal markers, routinely used in clinical practice, and neuropsychiatric outcomes is investigated and a control group is established in order to distinguish the markers which are truly predictive from those that are increased for other reasons but unspecific for hypoxic-ischemic damage.
Correlation between Perinatal Markers and Neuropsychiatric Follow-up after Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy: a Retrospective, Case-Control study
GALLERANI, MATILDE
2020/2021
Abstract
Hypoxic-ischemic encephalopathy affects around 3 newborns every 1000 term births per year. The only available treatment for hypoxic-ischemic encephalopathy is therapeutic hypothermia, which is performed on patients presenting with a moderate or severe encephalopathy. In this thesis study, the aim is to investigate the presence and the prognostic value of early perinatal markers able to predict the severity of the neuropsychiatric sequelae at 18-24 months in patients previously treated with therapeutic hypothermia. The correlation of perinatal markers, routinely used in clinical practice, and neuropsychiatric outcomes is investigated and a control group is established in order to distinguish the markers which are truly predictive from those that are increased for other reasons but unspecific for hypoxic-ischemic damage.È consentito all'utente scaricare e condividere i documenti disponibili a testo pieno in UNITESI UNIPV nel rispetto della licenza Creative Commons del tipo CC BY NC ND.
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https://hdl.handle.net/20.500.14239/13465