Gastroesophageal reflux disease in a condition affecting up to 5% of children older than 1 year of age. It presents with troublesome symptoms that can affect the quality of life of the patient. Pediatric gastroesophageal reflux disease diagnosis mainly relies on history taking and physical examination. Over the years many diagnostic tests have been studied but, to this day, none has been found superior to history taking and physical examination. The most promising diagnostic test are pH-impedance monitoring and esophago-gastro-duodenoscopy. Both tests have a moderate sensitivity and specificity for the diagnosis of gastroesophageal reflux disease in children but have many limitations. On the other hand, the eNose exhaled breath air analysis is a non-invasive test that can be performed in all medical settings for it consists of a small portable device. Consider all said above, with this study we hope to find a VOCs pattern specific for children with gastroesophageal reflux disease. This could ensue a less invasive and easier diagnostic test for pediatric gastroesophageal reflux disease.
A new diagnostic approach to pediatric gastroesophageal reflux disease: breath volatile organic compounds analysis by eNose. A cross-sectional pilot study.
SACCHI, SUVIANA
2021/2022
Abstract
Gastroesophageal reflux disease in a condition affecting up to 5% of children older than 1 year of age. It presents with troublesome symptoms that can affect the quality of life of the patient. Pediatric gastroesophageal reflux disease diagnosis mainly relies on history taking and physical examination. Over the years many diagnostic tests have been studied but, to this day, none has been found superior to history taking and physical examination. The most promising diagnostic test are pH-impedance monitoring and esophago-gastro-duodenoscopy. Both tests have a moderate sensitivity and specificity for the diagnosis of gastroesophageal reflux disease in children but have many limitations. On the other hand, the eNose exhaled breath air analysis is a non-invasive test that can be performed in all medical settings for it consists of a small portable device. Consider all said above, with this study we hope to find a VOCs pattern specific for children with gastroesophageal reflux disease. This could ensue a less invasive and easier diagnostic test for pediatric gastroesophageal reflux disease.È consentito all'utente scaricare e condividere i documenti disponibili a testo pieno in UNITESI UNIPV nel rispetto della licenza Creative Commons del tipo CC BY NC ND.
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https://hdl.handle.net/20.500.14239/13638