SARS-Cov-2 spread to China in 2019 and then, in the first months of 2020, to Italy, the remaining countries of Europe and the world, thus assuming the connotation of pandemic. The virus has not yet been eradicated and efforts are being made to control its spread. This paper looks at the virus by describing not only its morphological structure, but also its pathogenicity, showing which are the main initial effects and which are the most affected organs in the human body. Subsequently, we were interested in the macro-world of nanoparticles and their use in the fight against the pandemic, thus describing at first their use, very important, in the field of diagnostics, having regard both to their role in laboratory instrumentation and in the tests used for the most rapid and immediate detection of the virus. In a second moment we focused on the use of nanoparticles in the different therapies that have been administered until now to stem the spread of COVID-19, then paying attention to the role they play within vaccines. Finally, questions were asked about the emerging variants of the virus and their impact on diagnostic and vaccination methods.
La SARS-CoV-2 si è diffusa in Cina nel 2019 e successivamente, nei primi mesi del 2020, in Italia, nei restanti paesi d’Europa e del mondo, assumendo così la connotazione di pandemia. Ad oggi il virus non è ancora stato debellato e si lotta per tenere sotto controllo la sua diffusione. Questo elaborato pone lo sguardo sul virus descrivendo non solo la sua struttura morfologica, ma anche la sua patogenicità, mostrando quali sono i principali effetti iniziali e quali sono gli organi maggiormente colpiti nel corpo umano. Successivamente, ci si è interessati al macro-mondo delle nanoparticelle e al loro utilizzo nella lotta alla pandemia, andando così a descrivere in un primo momento il loro impiego, importantissimo, nel campo della diagnostica, considerando sia il loro ruolo nella strumentazione da laboratorio sia nei test utilizzati per il rilevamento più rapido e immediato del virus. In un secondo momento ci si è focalizzati sull’uso delle nanoparticelle nelle diverse terapie che fino ad oggi sono state somministrate per arginare la diffusione del COVID-19, ponendo poi attenzione sul ruolo che svolgono all’interno dei vaccini. Infine, ci si è interrogati sulle varianti emergenti del virus e sul loro impatto sui metodi diagnostici e vaccinali.
Nanotecnologie per il trattamento di SARS-CoV-2
PANARO, VERONICA
2020/2021
Abstract
SARS-Cov-2 spread to China in 2019 and then, in the first months of 2020, to Italy, the remaining countries of Europe and the world, thus assuming the connotation of pandemic. The virus has not yet been eradicated and efforts are being made to control its spread. This paper looks at the virus by describing not only its morphological structure, but also its pathogenicity, showing which are the main initial effects and which are the most affected organs in the human body. Subsequently, we were interested in the macro-world of nanoparticles and their use in the fight against the pandemic, thus describing at first their use, very important, in the field of diagnostics, having regard both to their role in laboratory instrumentation and in the tests used for the most rapid and immediate detection of the virus. In a second moment we focused on the use of nanoparticles in the different therapies that have been administered until now to stem the spread of COVID-19, then paying attention to the role they play within vaccines. Finally, questions were asked about the emerging variants of the virus and their impact on diagnostic and vaccination methods.È consentito all'utente scaricare e condividere i documenti disponibili a testo pieno in UNITESI UNIPV nel rispetto della licenza Creative Commons del tipo CC BY NC ND.
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https://hdl.handle.net/20.500.14239/14061