Migraine is a neurological disorder characterized by painful sensations localized in the head, potentially very disabling in daily life and in the long term in view of the risk of chronicity of the disorder. To fully understand the mechanisms of pain in migraine, the focus of this study is to investigate the differences between migraine sufferers and healthy controls regarding response to painful and non-painful thermal stimuli. The comparison was used as a guide for identifying the differences and consequently better understanding what were the causes and consequences related to the disorder. Patients with migraine were divided by type of diagnosis and after Offset Analgesia (OA) tests, the difference in pain perception and modulation was quantified. This difference was measured through Quantitative Sensory Testing (QST), considering the different pain and perception thresholds using thermal stimuli; the differences were noted not only between patients and healthy controls but also between the patients themselves, there are differences due to the different starting conditions and the different times in which the measurement was made. The QST was applied to all by measuring at the trigeminal level and in the extra trigeminal area, on the same side where the most pain was felt. Statistical analysis of these measurements highlighted how different migraine patients are from each other and from healthy controls, and how different the perception of pain is between people, thus indicating the need for personal understanding and specific therapy according to the analyzed case .
L’emicrania è un disturbo neurologico caratterizzato da sensazioni dolorose localizzate al capo, potenzialmente molto invalidante nella vita quotidiana e a lungo termine in considerazione del rischio di cronicizzazione del disturbo. Per comprendere appieno i meccanismi del dolore nel caso dell'emicrania, il focus di questo studio è quello di studiare le differenze tra chi soffre di emicrania e controlli sani per quanto riguarda la risposta a stimoli termici dolorosi e non dolorosi. Il confronto è stato usato come guida per l’identificazione delle differenze e di conseguenza capire al meglio quali fossero le cause e le conseguenze relative al disturbo. I pazienti con emicrania sono stati divisi per tipo di diagnosi e dopo i test di Offset Analgesia (OA), è stata quantificata la differenza nella percezione e nella modulazione del dolore. Questa differenza è stata misurata attraverso il Quantitative Sensory Testing (QST), considerando le diverse soglie del dolore e di percezione usando stimoli termici; le differenze sono state notate non solo tra pazienti e controlli sani ma anche tra i pazienti stessi, ci sono differenze dovute alle diverse condizioni di partenza e ai diversi tempi in cui è stata effettuata la misurazione. Il QST è stato applicato a tutti misurando a livello trigeminale ed in territorio extra trigeminale, sullo stesso lato dove si avvertiva più dolore. L’analisi statistica di queste misurazioni ha evidenziato quanto i pazienti con emicrania siano diversi tra loro e dai controlli sani, e quanto sia diversa la percezione del dolore tra le persone, indicando così la necessità di comprensione personale e terapia specifica a seconda del caso analizzato.
Soglie di percezione termica e meccanismi di controllo endogeno del dolore in pazienti con emicrania episodica e cronica
d'AMICO di S. DOMENICO, LORENZO
2021/2022
Abstract
Migraine is a neurological disorder characterized by painful sensations localized in the head, potentially very disabling in daily life and in the long term in view of the risk of chronicity of the disorder. To fully understand the mechanisms of pain in migraine, the focus of this study is to investigate the differences between migraine sufferers and healthy controls regarding response to painful and non-painful thermal stimuli. The comparison was used as a guide for identifying the differences and consequently better understanding what were the causes and consequences related to the disorder. Patients with migraine were divided by type of diagnosis and after Offset Analgesia (OA) tests, the difference in pain perception and modulation was quantified. This difference was measured through Quantitative Sensory Testing (QST), considering the different pain and perception thresholds using thermal stimuli; the differences were noted not only between patients and healthy controls but also between the patients themselves, there are differences due to the different starting conditions and the different times in which the measurement was made. The QST was applied to all by measuring at the trigeminal level and in the extra trigeminal area, on the same side where the most pain was felt. Statistical analysis of these measurements highlighted how different migraine patients are from each other and from healthy controls, and how different the perception of pain is between people, thus indicating the need for personal understanding and specific therapy according to the analyzed case .È consentito all'utente scaricare e condividere i documenti disponibili a testo pieno in UNITESI UNIPV nel rispetto della licenza Creative Commons del tipo CC BY NC ND.
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https://hdl.handle.net/20.500.14239/15624