This thesis focuses on the interaction between pancreatic cancer cells and normal fibroblasts following ionizing radiation exposure. The first part of this work, performed at the Academisch Medisch Centrum (AMC) of Amsterdam during my Erasmus period, describes the evaluation of Sonic Hedgehog signaling pathway modulation on Panc-1 cell line and responsive Mouse Embryonic Fibroblasts after X-rays radiation. The second part of the research was done at National Center for Oncological Hadrontherapy (CNAO) in Pavia and is aimed to evaluate the effects of different radiation qualities (X-rays and Carbon ions) on migration and invasion of Aspc-1 cell line and normal human fibroblasts AG01522.
Interaction between pancreatic cancer cells and normal fibroblasts after exposure to different radiation qualities: tumor migration, invasion and Sonic Hedgehog pathway
DI GIOIA, CARMELA
2015/2016
Abstract
This thesis focuses on the interaction between pancreatic cancer cells and normal fibroblasts following ionizing radiation exposure. The first part of this work, performed at the Academisch Medisch Centrum (AMC) of Amsterdam during my Erasmus period, describes the evaluation of Sonic Hedgehog signaling pathway modulation on Panc-1 cell line and responsive Mouse Embryonic Fibroblasts after X-rays radiation. The second part of the research was done at National Center for Oncological Hadrontherapy (CNAO) in Pavia and is aimed to evaluate the effects of different radiation qualities (X-rays and Carbon ions) on migration and invasion of Aspc-1 cell line and normal human fibroblasts AG01522.È consentito all'utente scaricare e condividere i documenti disponibili a testo pieno in UNITESI UNIPV nel rispetto della licenza Creative Commons del tipo CC BY NC ND.
Per contatti: unitesi@unipv.it
https://hdl.handle.net/20.500.14239/20536