Mathematical and numerical modeling of Human Induced Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) (Modelli matematici e numerici per cardiomiociti umani derivati da cellule staminali pluripotenti indotte (hiPSC-CMs)

Computational Cardiology is a research field which in the last two decades has known a great expansion and growing importance, thanks to the integrated improvement of cardiac mathematical models, numerical methods, computing platforms and biomedical data science. These novel techniques are becoming increasingly useful for both cardiac physiology and clinical practice. In this thesis, we will focus on the bioelectrical and mechanical aspects of Computational Cardiology, but we are aware that these aspects should be integrated with the study of cardiac haemodynamics and more in general of the cardiovascular system. We will start with the main mathematical models at both cellular and tissue levels, which provide essential tools to describe the main electrical and biological phenomena occurring through cellular membranes.