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Presepsin is a protein whose levels are claimed to increase specifically in the blood of patients with sepsis. It is proposed as a diagnostic and prognostic marker for assessing the degree of sepsis severity and it is constituted by a fragment of the soluble form of CD14 [sCD14-ST]. Baseline levels of Presepsin, though, have not yet been analyzed as an indirect marker of microbial translocation. The aim of the study was to evaluate the role of Presepsin in different categories of patients (HIV, HCV and coinfected patients HIV/HCV) and its correlation with immunoactivation markers as well as fibrosis scores. It also investigates how Presepsin concentration could be linked to levels of LPS, opening to the possibility of its employment as an indirect and easy-to-measure biomarker of microbial translocation.

Presepsin is a protein whose levels are claimed to increase specifically in the blood of patients with sepsis. It is proposed as a diagnostic and prognostic marker for assessing the degree of sepsis severity and it is constituted by a fragment of the soluble form of CD14 [sCD14-ST]. Baseline levels of Presepsin, though, have not yet been analyzed as an indirect marker of microbial translocation. The aim of the study was to evaluate the role of Presepsin in different categories of patients (HIV, HCV and coinfected patients HIV/HCV) and its correlation with immunoactivation markers as well as fibrosis scores. It also investigates how Presepsin concentration could be linked to levels of LPS, opening to the possibility of its employment as an indirect and easy-to-measure biomarker of microbial translocation.

The Role of Presepsin as an indirect marker of microbial translocation and immunoactivation

TOPPINO, SIMONE
2014/2015

Abstract

Presepsin is a protein whose levels are claimed to increase specifically in the blood of patients with sepsis. It is proposed as a diagnostic and prognostic marker for assessing the degree of sepsis severity and it is constituted by a fragment of the soluble form of CD14 [sCD14-ST]. Baseline levels of Presepsin, though, have not yet been analyzed as an indirect marker of microbial translocation. The aim of the study was to evaluate the role of Presepsin in different categories of patients (HIV, HCV and coinfected patients HIV/HCV) and its correlation with immunoactivation markers as well as fibrosis scores. It also investigates how Presepsin concentration could be linked to levels of LPS, opening to the possibility of its employment as an indirect and easy-to-measure biomarker of microbial translocation.
DIPARTIMENTO DI MEDICINA MOLECOLARE
2014
The Role of Presepsin as an indirect marker of microbial translocation and immunoactivation
Presepsin is a protein whose levels are claimed to increase specifically in the blood of patients with sepsis. It is proposed as a diagnostic and prognostic marker for assessing the degree of sepsis severity and it is constituted by a fragment of the soluble form of CD14 [sCD14-ST]. Baseline levels of Presepsin, though, have not yet been analyzed as an indirect marker of microbial translocation. The aim of the study was to evaluate the role of Presepsin in different categories of patients (HIV, HCV and coinfected patients HIV/HCV) and its correlation with immunoactivation markers as well as fibrosis scores. It also investigates how Presepsin concentration could be linked to levels of LPS, opening to the possibility of its employment as an indirect and easy-to-measure biomarker of microbial translocation.
BRUNO, RAFFAELE
Lauree a ciclo unico
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14239/21890