Schizophrenia (SCZ) is a psychiatric disorder that is characterized by hallucinations, delusions, a loss of initiative, and cognitive dysfunction. It is one of the severe forms of mental illness which demands enormous personal and economical costs. Insights that are beginning to emerge from psychology, neuroscience, and genetics suggest therefore possible strategies for moving forward. Advances in neuroscience methods over the past 50 years have provided the means to study complex psychiatric disorders in vivo, firmly establishing that disorders once viewed as psychological reactions to stressful environments (particularly family environments) are associated with subtle abnormalities in brain structure and function. The disorder is reported to include reductions in synapses, dysfunction of neurotransmitters, loss of gray matter volume, and alterations in brain connectivity architecture effects that together have been posited to lead to changes in neural communication efficacy and affected information integration. Gene mapping studies suggest that SZ is a complex disorder, with a cumulative impact of variable genetic effects coupled with environmental factors.
Schizophrenia (SCZ) is a psychiatric disorder that is characterized by hallucinations, delusions, a loss of initiative, and cognitive dysfunction. It is one of the severe forms of mental illness which demands enormous personal and economical costs. Insights that are beginning to emerge from psychology, neuroscience, and genetics suggest therefore possible strategies for moving forward. Advances in neuroscience methods over the past 50 years have provided the means to study complex psychiatric disorders in vivo, firmly establishing that disorders once viewed as psychological reactions to stressful environments (particularly family environments) are associated with subtle abnormalities in brain structure and function. The disorder is reported to include reductions in synapses, dysfunction of neurotransmitters, loss of gray matter volume, and alterations in brain connectivity architecture effects that together have been posited to lead to changes in neural communication efficacy and affected information integration. Gene mapping studies suggest that SZ is a complex disorder, with a cumulative impact of variable genetic effects coupled with environmental factors.
Genetic insights into schizophrenia: a clinical case report and a role for RB1CC1 duplications
PROVENZI, DANIELE
2016/2017
Abstract
Schizophrenia (SCZ) is a psychiatric disorder that is characterized by hallucinations, delusions, a loss of initiative, and cognitive dysfunction. It is one of the severe forms of mental illness which demands enormous personal and economical costs. Insights that are beginning to emerge from psychology, neuroscience, and genetics suggest therefore possible strategies for moving forward. Advances in neuroscience methods over the past 50 years have provided the means to study complex psychiatric disorders in vivo, firmly establishing that disorders once viewed as psychological reactions to stressful environments (particularly family environments) are associated with subtle abnormalities in brain structure and function. The disorder is reported to include reductions in synapses, dysfunction of neurotransmitters, loss of gray matter volume, and alterations in brain connectivity architecture effects that together have been posited to lead to changes in neural communication efficacy and affected information integration. Gene mapping studies suggest that SZ is a complex disorder, with a cumulative impact of variable genetic effects coupled with environmental factors.È consentito all'utente scaricare e condividere i documenti disponibili a testo pieno in UNITESI UNIPV nel rispetto della licenza Creative Commons del tipo CC BY NC ND.
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https://hdl.handle.net/20.500.14239/22834