The thesis discusses the new therapies for the treatment of Parkinson's disease. Parkinson’s disease is a chronic degenerative disease of the central nervous system, characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. For this reason, conventional drugs used for its treatment are dopamine-mimetic drugs, first of all Levodopa. Because of their serious side effects and unsatisfactory results of treatment, new strategies for the treatment of this disease are currently investigated, such as cell-based therapies. Initially these therapies were based on transplants with adrenal medullary, fVM tissues (fetal ventral mesencephalic) and other cells sources; but now efforts are devoted to the characterization and use of induced pluripotent stem cells (iPSC). These stem cells represent an interesting approach that can be used both for either the study of the pathogenesis of the disease and the development of new therapies for patients suffering from Parkinson's disease.
La tesi tratta delle nuove terapie per la cura del morbo di Parkinson. Il morbo di Parkinson è una malattia neurodegenerativa cronica del sistema nervoso centrale, caratterizzata dalla progressiva perdita di neuroni dopaminergici nella pars compacta della substantia nigra. Proprio per questa sua caratteristica, i farmaci convenzionali usati per la sua cura sono farmaci dopamino-mimetici, primo tra tutti la Levodopa. A causa però dei loro gravi effetti collaterali e degli insoddisfacenti risultati del trattamento, sono state indagate nuove strategie non farmacologiche per la cura di questa patologia, come per esempio le terapie a base di cellule. Inizialmente queste si basavano su trapianti con midollare del surrene, tessuti fVM (cellule dell’area ventrale mesencefalica) ed altre fonti di cellule; oggi si tende ad utilizzare le cellule staminali pluripotenti indotte (iPSC). Quest’ultime rappresentano un interessante approccio che può essere utilizzato sia per lo studio della patogenesi della malattia sia per offrire nuove terapie ai pazienti affetti da morbo di Parkinson.
Nuovi approcci sperimentali nella terapia del morbo di Parkinson
MORETTI, FRANCESCA
2015/2016
Abstract
The thesis discusses the new therapies for the treatment of Parkinson's disease. Parkinson’s disease is a chronic degenerative disease of the central nervous system, characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. For this reason, conventional drugs used for its treatment are dopamine-mimetic drugs, first of all Levodopa. Because of their serious side effects and unsatisfactory results of treatment, new strategies for the treatment of this disease are currently investigated, such as cell-based therapies. Initially these therapies were based on transplants with adrenal medullary, fVM tissues (fetal ventral mesencephalic) and other cells sources; but now efforts are devoted to the characterization and use of induced pluripotent stem cells (iPSC). These stem cells represent an interesting approach that can be used both for either the study of the pathogenesis of the disease and the development of new therapies for patients suffering from Parkinson's disease.È consentito all'utente scaricare e condividere i documenti disponibili a testo pieno in UNITESI UNIPV nel rispetto della licenza Creative Commons del tipo CC BY NC ND.
Per maggiori informazioni e per verifiche sull'eventuale disponibilità del file scrivere a: unitesi@unipv.it.
https://hdl.handle.net/20.500.14239/23018