The aim of this work is to compare pharmacological and phytotherapic treatments in order to prove the effectiveness of some topical medications in herpesvirus infections. A systematic review of the literature was conducted and some plants, like, licorice (Glycyrrhizza glabra L.), lemon balm (Melissa officinalis L.), sage (Salvia officinalis L.) rhubarb (Rheum officinalis Baill and Rheum palmatum a typicum L.) and terminalia chebula (Terminalia chebula Retz.) were found to have the property of reduce Herpesvirus infection's symptoms such as inflammation, pain and swelling. In various studies it was demonstrated how glycyrrhizic acid, extracted from licorice roots, is able to inactivate Herpesvirus and so to reduce the viral load. Citral A, Citral B and citronellal which are found in lemon balm have demonstrated their antiviral effect in different in vitro studies. Furthermore, aqueous-ethanolic extract of rhubarb titled in rhein associated with Salvia officinalis extract have shown the ability to inhibit Herpesvirus adsorption and penetration, proving then to be effective as anti viral treatment. Finally it has been demostrated that Terminalia chebula Retz. extract and its constituents, chebulagic and chebulinic acids, have a strong antiviral effect against Herpesvirus-2, due to the inhibition of viral adhesion and penetration into the host cells, if combined with acyclovir.
Scopo del presente elaborato è il confronto tra terapie farmacologiche con quelle fitoterapiche al fine di verificare l’efficacia di alcune preparazioni per uso topico nella cura dell’infezione da Herpesvirus. Dopo revisione della letteratura sono state elencate diverse piante, tra cui liquirizia (Glycyrrhiza glabra L.), melissa (Melissa officinalis L.), salvia (Salvia officinalis L.), rabarbaro (Rheum officinalis Baill e Rheum palmatum a typicum L) e terminalia chebula (Terminalia chebula Retz.), in grado di alleviare i sintomi principali causati dagli Herpesvirus, quali infiammazione, dolore e gonfiore. Numerosi studi hanno dimostrato come l’acido glicirrizzico, principio attivo estratto dalle radici di liquirizia (Glycyrrhiza glabra L.), sia in grado di inattivare l’Herpesvirus e quindi di ridurre la carica virale. Citrale A, citrale B e citronellale, presenti nell'olio essenziale di Melissa (Melissa officinalis L.) hanno mostrato effetti antivirali in studi in vitro. L’estratto etanolico del rabarbaro (Rheum officinalis Baill e Rheum palmatum a typicum L.) titolato in reina, in combinazione con l’estratto di salvia (Salvia officinalis L.) ha mostrato di poter inibire l’adsorbimento e la penetrazione del Herpesvirus, dimostrandosi quindi efficace come antivirale. Infine i risultati hanno mostrato che anche l’estratto di Terminalia chebula Retz. e dei suoi composti quali, acido chebulagico e acido chebulinico hanno mostrato una potente attività antivirale diretta contro Herpesvirus-2 nonchè l’efficacia di inibire l’adesione del virus e la sua penetrazione nelle cellule ospite, se confrontati con aciclovir.
Trattamenti farmacologici e fitoterapici nella cura dell'infezione da herpesvirus: confronto e nuove prospettive
TRAVERSO, NICOLETTA
2016/2017
Abstract
The aim of this work is to compare pharmacological and phytotherapic treatments in order to prove the effectiveness of some topical medications in herpesvirus infections. A systematic review of the literature was conducted and some plants, like, licorice (Glycyrrhizza glabra L.), lemon balm (Melissa officinalis L.), sage (Salvia officinalis L.) rhubarb (Rheum officinalis Baill and Rheum palmatum a typicum L.) and terminalia chebula (Terminalia chebula Retz.) were found to have the property of reduce Herpesvirus infection's symptoms such as inflammation, pain and swelling. In various studies it was demonstrated how glycyrrhizic acid, extracted from licorice roots, is able to inactivate Herpesvirus and so to reduce the viral load. Citral A, Citral B and citronellal which are found in lemon balm have demonstrated their antiviral effect in different in vitro studies. Furthermore, aqueous-ethanolic extract of rhubarb titled in rhein associated with Salvia officinalis extract have shown the ability to inhibit Herpesvirus adsorption and penetration, proving then to be effective as anti viral treatment. Finally it has been demostrated that Terminalia chebula Retz. extract and its constituents, chebulagic and chebulinic acids, have a strong antiviral effect against Herpesvirus-2, due to the inhibition of viral adhesion and penetration into the host cells, if combined with acyclovir.È consentito all'utente scaricare e condividere i documenti disponibili a testo pieno in UNITESI UNIPV nel rispetto della licenza Creative Commons del tipo CC BY NC ND.
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https://hdl.handle.net/20.500.14239/25671