Substance Use Disorders (SUDs) and Behavioral Addictions (BAs) are two prevalent disorders with shared neurobiological underpinnings. This meta-analysis aims to review and synthesize findings from resting-state functional magnetic resonance imaging (rs-fMRI) studies investigating the neural correlates of AUD (Alcohol Use Disorder), CUD (Cocaine Use Disorder), and Internet Gaming Disorder (ID). A comprehensive search of relevant literature yielded 67 studies that met the inclusion criteria. Findings from these studies were analyzed using Ginger ALE (activation likelihood estimation) meta-analytic software. The findings revealed consistent alterations in resting-state functional connectivity within reward circuitry, including the striatum, insula, and prefrontal cortex, in both SUDs and BAs, when compared to healthy controls (HC). The analysis also identified shared alterations in functional connectivity within cognitive control and emotion processing networks. These findings suggest impaired cognitive control and emotional dysregulation, which contribute to the development and persistence of SUD and BA. Despite these shared neurobiological features, the meta-analysis also highlights some distinct patterns of resting-state functional connectivity alterations between SUD and BA. For instance, CUD exhibited more pronounced alterations in hippocampal connectivity, while BAs showed more prominent alterations in insula connectivity. No consistent stronger patterns of activation were observed in ID than SUD. These findings suggest differential involvement of specific brain regions in reward processing and addiction between the three disorders. Overall, this analysis provides compelling evidence for shared and distinct neural correlates of SUD and BA by providing insight into the underlying mechanisms of these disorders. Further research is required in the domain of behavioral addictions to demonstrate conclusive evidence that ID shares similar or stronger neurobiological correlates than SUD.
Substance Use Disorders (SUDs) and Behavioral Addictions (BAs) are two prevalent disorders with shared neurobiological underpinnings. This meta-analysis aims to review and synthesize findings from resting-state functional magnetic resonance imaging (rs-fMRI) studies investigating the neural correlates of AUD (Alcohol Use Disorder), CUD (Cocaine Use Disorder), and Internet Gaming Disorder (ID). A comprehensive search of relevant literature yielded 67 studies that met the inclusion criteria. Findings from these studies were analyzed using Ginger ALE (activation likelihood estimation) meta-analytic software. The findings revealed consistent alterations in resting-state functional connectivity within reward circuitry, including the striatum, insula, and prefrontal cortex, in both SUDs and BAs, when compared to healthy controls (HC). The analysis also identified shared alterations in functional connectivity within cognitive control and emotion processing networks. These findings suggest impaired cognitive control and emotional dysregulation, which contribute to the development and persistence of SUD and BA. Despite these shared neurobiological features, the meta-analysis also highlights some distinct patterns of resting-state functional connectivity alterations between SUD and BA. For instance, CUD exhibited more pronounced alterations in hippocampal connectivity, while BAs showed more prominent alterations in insula connectivity. No consistent stronger patterns of activation were observed in ID than SUD. These findings suggest differential involvement of specific brain regions in reward processing and addiction between the three disorders. Overall, this analysis provides compelling evidence for shared and distinct neural correlates of SUD and BA by providing insight into the underlying mechanisms of these disorders. Further research is required in the domain of behavioral addictions to demonstrate conclusive evidence that ID shares similar or stronger neurobiological correlates than SUD.
The Neural Correlates of Addictive Substances and Behaviors: a resting-state fMRI meta-analysis of Alcohol, Cocaine and Internet Gaming Disorder
RITTER, MARC DOUGLAS ALEXANDER
2022/2023
Abstract
Substance Use Disorders (SUDs) and Behavioral Addictions (BAs) are two prevalent disorders with shared neurobiological underpinnings. This meta-analysis aims to review and synthesize findings from resting-state functional magnetic resonance imaging (rs-fMRI) studies investigating the neural correlates of AUD (Alcohol Use Disorder), CUD (Cocaine Use Disorder), and Internet Gaming Disorder (ID). A comprehensive search of relevant literature yielded 67 studies that met the inclusion criteria. Findings from these studies were analyzed using Ginger ALE (activation likelihood estimation) meta-analytic software. The findings revealed consistent alterations in resting-state functional connectivity within reward circuitry, including the striatum, insula, and prefrontal cortex, in both SUDs and BAs, when compared to healthy controls (HC). The analysis also identified shared alterations in functional connectivity within cognitive control and emotion processing networks. These findings suggest impaired cognitive control and emotional dysregulation, which contribute to the development and persistence of SUD and BA. Despite these shared neurobiological features, the meta-analysis also highlights some distinct patterns of resting-state functional connectivity alterations between SUD and BA. For instance, CUD exhibited more pronounced alterations in hippocampal connectivity, while BAs showed more prominent alterations in insula connectivity. No consistent stronger patterns of activation were observed in ID than SUD. These findings suggest differential involvement of specific brain regions in reward processing and addiction between the three disorders. Overall, this analysis provides compelling evidence for shared and distinct neural correlates of SUD and BA by providing insight into the underlying mechanisms of these disorders. Further research is required in the domain of behavioral addictions to demonstrate conclusive evidence that ID shares similar or stronger neurobiological correlates than SUD.È consentito all'utente scaricare e condividere i documenti disponibili a testo pieno in UNITESI UNIPV nel rispetto della licenza Creative Commons del tipo CC BY NC ND.
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https://hdl.handle.net/20.500.14239/3142